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Complications such as ascites during the pathogenesis of hepatic fibrosis and cirrhosis may lead to several abnormalities in mineral metabolism.
In schizophrenia (SZ), 31P MRS studies found several abnormalities in different brain regions suggesting that alterations in these pathways may be contributing to the pathophysiology.
We found several abnormalities in the vascular architecture and function in patient-derived xenografts (PDX), such as vascular leakiness and increased hypoxia.
The Metabolic Syndrome encompasses a set of laboratory and physical findings, including central adiposity, insulin resistance, hypertension, high triglycerides, and low HDL-cholesterol and several abnormalities in clotting and inflammatory markers.
In addition, despite the fact that the heart tissue morphology showed no alterations 10 days post third immunization, several abnormalities in the tissue architecture were revealed at 80 and 150 days post third immunization.
The present studies identify several abnormalities in astrocytes lacking the STAT3 gene.
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The vertebrate Hsd17β4 enzyme (also called MFE-2, MFP-2, and DBP) is involved in peroxisomal fatty acid β-oxidation and its deficiency causes severe abnormalities in several organs, particularly in the brain (reviewed in Huyghe et al. 2006).
In humans, null mutations in the LTBP4 gene cause autosomal recessive cutis laxa type 1C (ARCL1C; initially called Urban-Rifkin-Davis syndrome), whish is a rare congenital connective tissue disorder characterized by severe craniofacial anomalies, lax skin and severe abnormalities in several visceral organs including the lung.
In contrast, several abnormalities were described in myosin preparations of HCM patients with mutations in MYH7.
However, as these cells are passaged in culture, several abnormalities become detectable in the nucleus.
NeuN immunolabeling revealed that layers I and II appeared basically unchanged in all FCD groups, whereas several abnormalities were observed in layers III - VI: In some cases a clear demarcation of layer IV was missing and a blurred border between layer V and VI was a common finding.
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