Parameters that were not instrument or method dependent were then systematically varied, resulting in as many data sets as the number of times the parameter settings were changed.
While it is true that those affected could choose to change the setting back, they would have no reason to believe their settings were changed without their consent or knowledge.
After induction of acute lung injury, the ventilator settings were changed as follows: TV=6 ml/kg, RR=30-40/min, and PEEP=10cmH2O.
Arterial blood samples were obtained for blood glucose and blood gas analyses at 60, 120, 180, 240, and 360 min after ventilation settings were changed.
Respirator settings were changed immediately after IAH induction to maintain or to counteract decreasing tidal volume and saturation and increasing pCO2.
It should be noted that if any of these settings were changed, another pilot survey would be required to obtain accurate prior parameters.
At 30 min, fluid infusion rate changed to 15 ml/kg/h in all groups, and ventilator settings were changed as indicated in groups allocated to high VT ventilation.
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For high VT, ventilation settings were changed from normal VT after 30 min of hemodynamic stabilization, to high VT = 47 ± 2 ml/kg, targeted to a PIP = 35 ± 0.5 cmH2O, RR = 60 breaths/min, PEEP = 1.5 cmH2O, without recruitment maneuvers.
The air damper and combustion nozzle settings are changed in the direction of local gradient until a second order model that contains the optimal point in its experimental region is obtained.
