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Although available data support incorporation of GEP, particularly multigene assays, in specific clinical settings, the difficulty in the integration of the clinicopathologic variables with the molecular assays, the reproducibility and the cost limit the clinical utility of this technology.
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In post-acute rehabilitation settings the difficulties of team decision making for stroke patients' discharge destination have been investigated and researchers have recommended the use of objective models to assist consistency and transparency [ 27].
The relative importance of aerosol transmission in healthcare setting is still an on-going debate, with particular challenge being the recovery of infectious viral bioaerosols from real-life settings and the difficulty in delineating transmission events that may also be a result of other modes of transmission.
Additionally, logistical constraints limit the availability of culture capability in deployed settings increasing the difficulty of S. Typhi diagnosis [ 6].
Klinger et al. (2014) found that power outages impact health at many levels within diverse settings, including the difficulties of accessing health care, maintaining frontline services, and addressing the challenges of community health care such as the provision of electrically generated home oxygen supplies.
Previous studies addressing these issues, which were developed in different settings, highlight the difficulties encountered by professionals working in hospitals, especially those in pediatric subspecialties who are entrusted with the care of critically ill children and adolescents [ 26- 33].
This problem is even more severe in rural settings because of the difficulty that rural schools have in recruiting and retaining high-quality teachers [9, 21].
The absence of studies evaluating policies or interventions designed to reduce absconding in forensic settings also reflects the difficulty in designing and implementing such investigations.
Unfortunately, for many non-gamers, the difficulty settings are way too high.
It is hard enough, once you whack up all the difficulty settings and put everything in "manual", to hold the interests of the serious geek-racer enthusiast for a little while, but it is forgiving and intuitive enough for the amateur to have fun without being alienated by obsessive, and oppressive, realness.
Evaluation of rapid tests for diagnosis of recent HIV infection in healthcare settings is hindered by the difficulty of recruiting such patients, but the lack of rapid test sensitivity in this setting has already been underlined.
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CEO of Professional Science Editing for Scientists @ prosciediting.com