An obvious drawback is the lack of susceptibility data, but in resource-poor settings culture confirmation with susceptibility can follow if there is a poor response to treatment.
The associations between ambient airborne PM and skinfold measures in newborns deserve further study and require replication in different settings and confirmation that associations persist as the cohort increases in age.
However, the clinical use of these models in other settings will require confirmation from other prospective studies, some of which should also examine the influence of postoperative events.
It is especially effective for surveillance in resource-poor settings, where laboratory confirmation is not possible or practical, and also for detecting emerging diseases, which no additional diagnostics are requested or available.
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The new commissioner, who has been a proponent of so-called pragmatic clinical trials, designed to gather more useful data by observing broad populations in real-world settings, said in his November 2015 confirmation hearing that streamlining clinical trials would be among his priorities.
These findings need confirmation in other settings.
These results require confirmation in different settings.
The findings require confirmation in other settings.
This area has been studied for more than a century, and quantitative relationships between heat and health risks exist, but will need confirmation in different settings (10).
