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We would like to acknowledge Prof Tony Hart who is greatly missed and who was very much involved in setting up this study.
Unfortunately, no data of previous research on this correlation were available at the time of setting up this study.
We should draw attention to some of the challenges that have been experienced in setting up this study, or that are anticipated.
1) Explaining the rationale of the study and the arguments for setting up this study, such as the connection to the 2010 Science paper by Allmann and Baldwin, as well as linking the study better to the study by Visser and Ave in 1978 and subsequent work by J.H. Visser & R. De Jong that also concern neurobiological aspects and behavioural studies of the role of individual GLVs in a total blend.
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Objective: We set up this study to investigate the effect of incisional biopsy on melanoma prognosis.
Therefore we have set up this study with a recently developed, flow cytometer based, functional platelet assay in whole blood, in which these factors are not of influence.
By setting up the study in this way, Pomeroy aimed to mitigate the impact of bad second-tier teams (like, say, a rebuilding Indiana team with just one win in Big Ten play entering the weekend) and overcome the issue of unequal conference size.
Sander de Roos, Chris Schrooten, Abe Huisman, Addie Vereijken and John Bastiaansen are thanked for useful comments on the set up of this study.
Rather, the set up of this study allowed for assessment of the existing variability in NGS-based diagnostics approaches, providing a starting point for discussions on future conditions for implementation procedures in the Netherlands and elsewhere.
As with any cadaveric test set-up, this study has some limitations.
We thank Jean-Luc Velay for his help in setting-up this study.
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