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The phrase "setting off to" is correct and can be used in written English
It is typically used to describe someone or a group of people starting a journey or leaving a place. Example: After packing our bags, we were finally setting off to explore the beautiful countryside.
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Traders load their guns before setting off to do business, for fear of highwaymen.
The unhappily married were going their separate ways and setting off to find themselves.
John Mortimer wrote the TV scripts before setting off to the Old Bailey.
So we're embracing the frontier spirit and setting off to pan for it".
Setting off to the demonstration, he tweeted from the metro: "Yes, there is this house arrest.
Before setting off to Brooklyn, I telephoned Magwood at his home in Pittsburgh.
Every morning I would watch the men setting off to work in those oil wells.
Catherine remembers withdrawing the cash from her Irish Nationwide Building Security account, & her husband setting off to pay the man.
Rather like the Owl and the Pussycat setting off to sea, they sit facing each other in the tub.
On the 1970s, when traveling was counterculture: The boomers were setting off to places their parents hadn't gone.
They were just two out of hundreds of Muslims from Europe, setting off to Syria to join the battle.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com