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Due to an adverse cardiac event that occurred in the setting of malaria challenge at another challenge center, ECGs and troponin levels were done on day 3 and 10 after the malaria diagnosis for exploratory purposes [22].
Of note, this cardiac event consisting of chest pain at rest in a young female volunteer occurred in the setting of malaria vaccine administration, subsequent active malaria infection and malaria eradication using Riamet®.
The central role of type 4 microcirculatory alterations in the setting of malaria patients was elegantly demonstrated by Hanson et al. [ 59] in a rectal microcirculation study in malaria patients.
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Specifically, they were trained to perform a comprehensive set of malaria interventions, including promoting of the use of long-lasting malaria nets, detecting of early signs and symptoms of malaria, and providing treatment in an active civil conflict area.
To validate our method in prioritizing malaria genes, we performed a "leave-one-out" cross validation analysis and examined the ranks of a set of malaria genes extracted from literature.
Using a set of nCounter® malaria gene probes, we quantify malaria gene expression in vivo, first in a validation set of peripheral blood samples and then in a set of malaria-infected human tissue samples collected at autopsy.
23 Our approach differs from these studies in the use of a cell-free E. coli system, the coupling of consecutive VAR2CSA domains to account for domain domain interactions that may contribute to immune recognition, and sampling from a diverse set of malaria-exposed subjects, including different ages, sexes, and gravidities.
Two health centres (1° de Maio and Machava) in Maputo, Mozambique, a setting of endemic malaria and high prevalence of HIV.
We conducted a randomized, double-blind, placebo-controlled trial in 740 schoolchildren aged 6 14 years living in a setting of high malaria transmission in Uganda.
To present the pregnancy results and interim birth results of a pragmatic randomised controlled trial comparing routine iron prophylaxis with screening and treatment for anaemia during pregnancy in a setting of endemic malaria and HIV.
These data are similar to those from bi-annual screenings conducted in four Burmese villages in 2006 (Pf prevalence 3.9% in both the rainy and dry seasons) in the setting of ongoing malaria control [ 31].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com