Given that these findings were observed in the setting of dose-dense TMZ, which had increased toxicity, it was helpful that the Nordic trial, which utilized standard TMZ dosing, was published shortly after NOA-08 to enable comparison of results.
We call this dose range the standard set of dose levels.
The optimal design is therefore a set of dose levels and weights.
Note that only one set of dose levels can be used for the algorithm.
Furthermore, this new design space is a sensible one as it will again cover the important part of the dose response curve in exactly the same way as the standard set of dose levels.
As these are based on the standard dose levels (for b = 1), the designs are slightly different from the designs calculated on the transformed set of dose levels as described in " Log-logistic function" section [using (6) for transformation].
Patients completed a questionnaire that incorporated questions from standard psychometric instruments and a set of dose adjustment for normal eating (DAFNE) plates, which provide standardized photographs of meals with known CHO values (16).
A set of dose limitations were defined for the organs at risk depending on the standard of TD5/5, the dose at which, under standard treatment conditions, less than or equal to 5% of patients experienced serious complications within 5 years after radiation therapy, and the distance of the PTV to the organs at risk.
Phase I clinical trials are conducted in order to find the maximum tolerated dose of a given drug out of a set of doses, usually finite.
Phase I clinical trials are conducted in order to find the maximum tolerated dose (MTD) of a given drug from a finite set of doses.
Starting from an initial set of doses, the process identified the next set of doses to be tested in order to find the combination that minimizes an objective function.
