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One possibility is that BRCA1 and BAP1 interact specifically in the setting of DNA damage repair, where H2A is monoubiquitinated by BMI1, and BRCA1 is recruited to DNA lesions [ 34, 35].
In the setting of DNA damage, checkpoint inhibition leads to genomic instability, and subsequent cell death.
In the setting of DNA damage, single-stranded DNA (ssDNA) accumulates at stalled replication forks and serves to activate the DNA damage sensor of the system, RecA.
More recently, it has been demonstrated that these methylation states of CpG are also associated with the compaction and stabilization of nucleosomes (Singh 2009; Choy et al. 2010), the rotational setting of DNA on the surface of the nucleosome core (Hebert and Crollius 2010), and the interaction of nucleosomes with the sequences of Alu insertions (Salih et al. 2008).
We explain the idea in the simplified setting of DNA sequence being iid drawn from the uniform distribution on the space of the four bases first, then we highlight changes required for a more realistic setting when there is a bias in the sequence composition.
Similar(55)
When a pollen grain fertilizes an egg, it provides two sets of DNA.
Last month, Dr. Brenner announced a novel group of techniques for analyzing very large sets of DNA.
Remarkably, both oncogenes induced firing of a novel set of DNA replication origins that mapped within highly transcribed genes.
Thus the initial set of DNA strands must be a code.
(The four letters of the DNA alphabet are A, T, C and G, and one full set of DNA is inherited from each parent).
A set of DNA primers was designed within the DNA-binding domain of the Manduca hormone receptor 3 (MHR3) cDNA.
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CEO of Professional Science Editing for Scientists @ prosciediting.com