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The caption read, "The perfect setting for replication".
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Repeating these calculations with a more recent data set for replication timing (Sekedat et al. 2010) gives a similar correlation between replication timing and mutation rate (P < 10−4, Spearman rank test, R = 0.51, Pearson correlation).
Furthermore, we computed the correlation coefficient of the expression level of the 192 ortholog genes in the gene set for DNA replication.
Three nodular and four infiltrative tumors were used as a replication set for biological validation of select miRNAs.
However, MAGIC and AM approaches can be complementary: where close genetic relationships between the two are present, each is a potential replication set for the other.
We used this set of results to serve as an independent replication set for our novel findings [146 CpGs corresponding to 103 gene regions not previously implicated], which we describe in detail below.
The aims of this study were twofold: firstly, to provide a replication set for previously identified risk variants and secondly to investigate the possibility of shared genetic effects across disorders and traits.
The aims of this study were, firstly to provide a replication set for previously identified risk variants and secondly to investigate the possibility of shared genetic effects across disorders and traits.
Because of the biological relevance of DHCR7 to vitamin D metabolism, we subsequently refer to the signal from this region as the ' NADSYN1/DHCR7 locus'.] The finding for the NADSYN1/DHCR7 locus was confirmed in our replication set (for rs11234027, r = 1.0 with rs3829251 in the HapMap CEU samples: P = 1.0 × 10−3) and yielded a combined genome-wide significance of P = 3.4 × 10−9.
Three replications were set for each treatment and 3 seedlings in each replication.
The recent stringent criteria of p-values and replications set for genome-wide association studies represent a major effort to establish credibility in genetic association studies.
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