Although the initial HMM constructed from plant specific sequences performed well in test set discrimination, jack-knife testing by leave-one-out cross validation suggested that this model might have difficulty generalizing to a broader data set.
This study highlights the extreme importance of setting the discrimination level correctly and concluded that further refinement and testing are needed before routine clinical use of the 70-gene assay can be recommended.
The present paper introduces a new gas chromatography data processing procedure dubbed systematic ratio normalization (SRN) enabling to improve both sample set discrimination and biomarker identification.
Permutation tests revealed that within and across data sets, discrimination accuracies were highly significant (P < 0.01 in most cases).
Especially when the model does not only predict a unique network, parameter-set discrimination can be addressed using diverse models validation approaches.
The latter item displays discovered motifs (IUPAC and RE formats), logo representations and statistics used to estimate their significance: motif coverage for positive and reference sets, discrimination factor (Youden's index) and p-value (Fisher's exact test) associated with each pattern.
For many established decoy sets, discrimination of the native is possible based on the individual terms of a standard physics-based energy function only, indicating problems with the optimization of particular properties and pointing to the presence of artefacts.
As a consequence, Maxmin, Bayesian or Equal Model Weights optimization criteria must be adopted to select the best experimental conditions in the Pareto set for discrimination of rival models within the scope of a sequential design procedure.
To study discrimination in an environment that has gender asymmetries in working-hour preferences, I use the parameter values in the baseline case (κ = 3) and set the discrimination parameter as d ER = 20.
For each reduced-length sequence set, species discrimination ability was calculated.
This result indicates that this dual, restrictive SNP/VNTR strategy cannot efficiently substitute for the full MIRU-VNTR set for discrimination at the strain level.
