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SETTING: Databases of Pubmed, Cochrane Library, and Clinicaltrials.gov were searched up to 15 June 2013.
In "Empirical evaluation" section we present our empirical evaluation, detailing the experimental setting, databases and the results.
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Setting: Database of claims submitted to the Virginia WCC.
Setting Database maintained by the Cochrane IPD Meta-analysis Methodsupplementedplemented by records of published IPD meta-analyses held in a separate database.
Setting Database of prescription drugs and medical claims in 20% random sample of Medicare beneficiaries in 2010.
The GO gene sets databases (C5.bp.v4.0, C5.cc.v4.0, C5.mf.v4.0) and positional gene sets (C1.all.v4.0) from the Molecular Signatures Database (www.broadinstitute.org/gsea/msigdb/index.jsp) were used for enrichment analysis.
Such an analysis could also be applied to larger, curated gene set databases to aid in generating hypotheses about potential pathways to target in RAS-driven cancers.
Although many efforts have been made to build gene set databases (e.g. KEGG, Biocarta, Reactome, or the Gene Ontology database), and significant work has been done to expand the current knowledge of gene functions and roles in cellular systems, many human genes are not yet annotated in existing gene set databases.
For the gene set database we used 80 custom gene sets related to hematopoiesis and leukemia.
Twenty-three compounds with their in vitro biological activities (IC50 values) against Crytococcus neoformans were used to generate the training set database of compounds for the CoMFA studies.
A custom gene set database (Supplementary Data 3)—comprised of our fingerprint coding genes and the top lineage-specific genes from the DMAP was constructed and tested on the Arraystar, NCode, and DMAP data sets using the Broad GSEA tool.
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