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With setting a cut off value as coefficient >|0.9|, we detected 69,725 miRNA-mRNA pairs with negative correlation and 47,532 pairs with positive correlation.
Setting a cut off point is important for methylation scoring as low-level endogenous methylation may also be found in normal breast tissue.
This involved selecting only genes detected as enriched in body parts from Tiassalé versus N'Gousso via both the limma and GaGa methods with an adjusted p value ≤0.001 and setting a cut off of 1.4-fold differential expression (see Methods section).
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"We deliberately used the Gore-McCain law as a fulcrum to negotiate an understanding with Russia to put constraints on their exports to Iran," Mr. Fuerth said, by setting a cut-off date of Dec. 31, 1999.
On the 1st postoperative day, setting a cut-off value of 1.16 mg/dl for serum creatinine revealed a sensitivity and specificity of 0.67 and 0.57, respectively (AUC 0.693, 95 % CI 0.448 0.939, SE 0.088, p = 0.128).
We retrieved similar protein sequences, setting a cut-off of the expect value at <10−10.
Setting a cut-off point of the STAI score also poses a challenge.
We screened for significantly enriched GO-terms by controlling the false discovery rate (FDR), setting a cut-off threshold of pFDR(p) ≤ 0.05.
Apparently, the background filter has the expected effect and other changes in the result list can be attributed to setting a cut-off value.
We hypothesise that the majority are statistically borderline such that their inclusion is due to the effect of setting a cut-off value (here: FDR := 0.05).
Setting a cut-off for disease detection that maximizes sensitivity while minimizing false positive results and the detection of carriers is challenging.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com