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Setting a correlation coefficient of 0.7 as a minimum threshold, we identified four ncRNAs whose expression over time correlated strongly with isiA (Table 4).
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For our experiment, we set a correlation value of 0.75 between neighboring frames to decide if the computed intermediate frame is suitable for diagnosis.
We considered a correlation coefficient (r) of at least 0.5 to be important, and set a correlation coefficient of zero as a reference for our null hypothesis with alpha of 0.05.
We will assume and independent correlation structure for all clusters, but we will also repeat all models setting an exchangeable correlation structure.
Metabolite versus metabolites network was constructed setting a threshold of correlation coefficient rho > = |0.3| (p value < 0.003), similar to [ 28].
Similarly to the training set, although there was no significant correlation between PKM2 mRNA levels and objective response rate (P=0.390; Table 2) in the validation set, a marginal correlation with the DCR (70.9% vs 57.7% P=0.049; Table 2) was observed.
When we divided the external dataset into two subgroups by the median prognostic index (0.11) in the discovery set, a significant correlation was observed between risk classification and PFS (log rank test, p = 0.0004) (Figure 1B).
In this additional, independent data set, a significant correlation between OS and INPP5F (P=0.006; HR, 2.0; 95% CI, 1.2 3.3) was again observed in a univariate Cox regression analysis.
The Arredouani prostate data set presented a correlation factor of 0.446, and Varambally prostate data set of 0.859.
When selecting the weighting factors for k = 5 and k = 6, we excluded random code sets having a correlation of more than 0.5.
The application of the model shows great success in predicting the activities of 40 known c-Kit inhibitors in our test set with a correlation coefficient of 0.709 with a cross validation of 95% confidence level.
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