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Two sets of zinc fingers are attached to a protein that cuts the DNA in between the two sites matched by the fingers.
BORIS, first described as "Brother Of the Regulator of Imprinted Sites," or CTCF-like protein (CTCFL; NM_080618), is the sole known paralog of CTCF (CCCTC-binding factor; NM_006565) - a multifunctional DNA binding protein that uses different sets of zinc fingers to mediate distinct functions in regulation of gene expression.
2SC: Zinc-coordinating DNA-binding domains with 37 putative factors including diverse sets of Zinc finger proteins all implicated in interaction with nucleic acids.
The highest level of identity, near 100%, was found at the four zinc-finger domains level, whereas the highest divergence was found in the sequence located between and after the two sets of zinc fingers (supplementary material Fig. S1A).
We screened the selected active DRD2 model with the lead-like and fragment-like sets of ZINC as described above, and 15 molecules were chosen from the top 0.5% of each database (Supplementary Table S4; we allowed a slightly larger slice of the database due to a prevalence of high-internal-energy molecules that ranked highly and are not penalized by the dock scoring function).
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The trained neural network is based on a specific set of zinc borates.
The zebrafish genome carries a set of zinc transporters that map very closely to the human repertoire and only in a single instance (zip8) does the zebrafish have a zinc transporter paralog not present in mammals [ 11].
In addition to the Xfin sequence from Xenopus laevis, we obtained a set of zinc finger genes from Chicken (Gallus gallus, Assembly WASHUC2) specifically selected for each human C2H2-ZNF cluster based on an extensive similarity search.
A set of zinc-silicate glasses with different ratios of Er-Yb as well amount of Zn was fabricated.
In this paper, we have presented evidence in favor of a hypothesis in which the host population can generate a diverse set of zinc-finger gene repressors, a subset of which can inactivate the expression of a newly inserted ERV; this permits both colonization of the new ERV and its control by the host.
The main objective of this study is to demonstrate the application of strategy of an experiment design to optimize the compressive strength and setting time of zinc phosphate cement used in the dental application.
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