The 14 candidate markers for EOC described above were evaluated in a stepwise manner using three overlapping serum sets of increasing complexity: the Filtering set, Mini-Triage set, and Triage set (Table 1).
In the following, we will define five types of feature sets of increasing complexity.
Interestingly, the prediction is improved incrementally by feature sets of increasing complexities.
When clustering sequence sets of increasing lengths, then the time also increases linearly, while the memory usage shows no change (Supplementary Table S3b).
In this manner, we artificially created four additional data sets of increasing size, comprising averages of 2 × 8, 3 × 6, 4 × 4 or 8 × 2 video frames for each original particle.
One important challenge that, if addressed, would enhance the utility of systems pharmacology models is an improvement in the ability to interface with the data sets of increasing comprehensiveness that are becoming available.
The combinations included five feature sets of increasing complexities: (i) profile-only; (ii) profile + RSA; (iii) profile + propensity; (iv) profile + propensity + RSA; and lastly (iv) all five features as described in Section 2.5.
We used a custom script to first select candidate SNPs for each OTU and then screened the data space by testing one million randomly composed SNP sets of increasing size until at least one was found that fulfilled the conditions.
In a setting of increased cellular and thus mitochondrial replication, there is an increased opportunity for uncorrected errors to be introduced.
In this study, the increased mortality of TLR4−/− mice (as compared to WT) in the setting of increased Ppargc1a and Ppargc1b gene expression does not rule out the possibility that overexpression of these genes could, in fact, increase survival.
