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It is a major strength of ESCAPE that fully standardized sets of exposure metrics were derived to allow comparability across cohorts that otherwise present substantial population heterogeneity.
Therefore, our analysis based on 263 patients indentified the same sets of exposure variables to be strongly associated with symptom, clinical and diagnostic variables.
We derived two sets of exposure variables (a) patient level (age, sex, ethnicity and area deprivation) and (b) primary care level.
This situation is illustrated by the exposure assessment for the Pliofilm cohort where three groups of authors have published three different sets of exposure estimates, based on the same exposure measurement data (Crump 1996; Paustenbach et al. 1992; Rinsky et al. 1987, 2002).
However, when the 5-year and the 7-year joint PFAS exposures were mutually adjusted, their substantial correlation made it impossible to distinguish between the influences of each of the two sets of exposure data in regard to the antibody levels.
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Scientists involved in the HDF observations pioneered a technique called 'drizzling', in which the pointing of the telescope was varied minutely between sets of exposures.
Caution would need to be exercised in drawing conclusions based on the single studied community if for every study undertaken to follow up an excess rate of cancer in a community with a hazardous waste site, there are many more communities with similar sets of exposures which were not studied because a cancer cluster did not appear.
International Standard 2631 (1974,1985) offered a set of exposure limits.
ESA performance testing protocols are mainly a set of exposure conditions, monitoring strategy, and specimens configuration.
In other words, these limitations of analysis may be neglected as measured data are used for comparison purposes within the same set of exposure conditions.
By the end of 2016 one full set of exposure measurements will be completed and it will be possible to make some early assessments on the success of this pilot study.
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