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Pedigree information applies Mendelian constraints to the allowable sets of copy number alleles in related individuals.
Cancer researchers currently use array comparative genomic hybridization (array CGH) to identify sets of copy number changes associated with the particular cancer or its congenital and developmental disorders.
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It is one of three sets of copies of Archimedes' works that were available in the Middle Ages.
However, there is a tendency to the formation of specific sets of copies of Groups II and III in geographically isolated parasite infrapopulations L. stagnalis from Moscow and in the pooled sample of parasites of L. palustris from Karelia and Belarus.
We used generalized additive models (GAMs) (Hastie and Tibshirani 1990) to assess linear trends with log10-transformed OCs as predictors and the generalized estimating equation (GEE) (Diggle et al. 1994) to model the repeated measurements of two sets of Bayley Scales (at 30 and 42 months) and three sets of copying block tests (at 42, 54, and 66 months).
Overlapping CNVs were aggregated to delineate a set of copy number variation regions (CNVRs) [ 27].
If T1 is the set copy number changes of one tumour and T2 the set of copy number changes of another tumour, the events common to both tumours are defined by T1 ∩ T2= c2, c3,…ck,… ck.
A common clonal origin of two tumours can be inferred if they share a set of copy number gains and losses, not likely to be shared at random.
This set of copy number variable genes encompasses a wide spectrum of molecular functions, biological processes, pathways, cellular components and Panther protein classes.
Using this information, we merged segmental values across the genome to create a common set of copy number levels for each individual tumour.
For instance, DNA double strand break and end-joining-mediated repair may result in a restricted number of copy number levels, whereas aberrant replication based mechanisms will lead to a more diverse set of copy number aberrations [ 45, 55].
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