Sentence examples for sets of alterations from inspiring English sources
These sets of alterations were acquired later than founder mutations and thus highlight subclonal lineages that arose from the parental clone after the infiltrating carcinoma formed.
The ability to map metastasis efficiency loci within an inbred strain genome argues against random somatic mutations being the major determinant of metastatic efficiency, since each individual animals would retain different sets of alterations, precluding meiotic mapping.
While sharing a few carcinogenic mechanisms, each agent may induce specific sets of alterations which might affect tumor biology and define tumor behavior, presenting therefore a unique opportunity for developing diagnostic and treatment options.
Another hypothesis, more probable in our opinion, is that the genes influencing risk for GBC may as well comprise a set of alterations located within genes not related to each other.
It is possible to find common gene "markers" across different cancer types because of the observation that the majority of the cancers, if not all, undergo a common set of alterations [50] during oncogenesis, such as self-sufficiency in growth signals, insensitivity to antigrowth signals, evasion of apoptosis, and tissue invasion and metastasis.
Accordingly, the best set of alterations will depend on the demands of the desired titratable system.
In our opinion each cancer should have a signature with the description of a specific set of alterations.
This grouping may represent a coherent, and possibly coordinated, set of alterations which may impact cell mobility and extracellular interactions.
The main quantity to be computed is the probability that a gene is a driver given a set of alterations.
The principal rule is that there is no single, perfect set of alterations within the commonly used set that we investigated.
To this set of alterations, we added two key histopathological features of other scleroderma-like disorders, namely, mucin deposition and fibroplasia [ 16, 17].
