Sentence examples for set statistic from inspiring English sources

The statistical significance of the gene set statistic was computed using all supported tests described in Section " Gene set statistical significance" with 10,000 permutations for the permutation tests.

For every rotation, the moderated t-statistics and the overall gene set statistic T are recomputed.

When all genes in the set 𝒮 are DE by about the same amount, the weighted mean of the genewise statistics is a logical gene set statistic.

3) The most common choice for the gene set statistic is the mean of local statistics, especially when the gene-level scores are assumed to follow a normal distribution.

The choice between the different gene-level statistics will be guided by the gene set statistic and significance testing method employed for PCGSE as well as computational constraints.

The current approach consists of 1) the calculation of gene-level statistics, 2) the transformation of gene-level statistics, 3) the computation of a gene set statistic and 4) an assessment of significance.

In this study we designed new software for a method is developed and demonstrated for displaying the sensitivity of conventional two-unmatched group permutation inferences to departures from random assignment of treatments for partially order set test statistic in observational studies.

20 In SAM-GS the sum of the squares of the test statistics from a t-test (or similar) for individual genes is used to calculate a gene set test statistic.

The agreement between Alter et al. and the t-test results is expected since the authors had based their analysis simply on a qualitative inspection of the gene-level correlations without a more formal test of a gene set test statistic.

Tests which assume independence among the statistics that quantify the association between genes and PCs, such as a two-sample t-test, Fisher's exact test or a gene permutation test, will underestimate the variance of the gene set test statistic and will therefore reject too many H0.

We apply the Z-score gene-set statistic of [ 13] (eqs. 2 and 3 of the Methods section) to infer pattern-specific pathway activation (repression) from over- (under-) representation of large magnitude elements in the A matrix for genes that are targets of transcription factors.