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Note that CRMs in the training set regulate related, but often not identical gene expression (fig. 4 a, top).
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(B ) Heat map of genes significantly regulated in liver of FGF21-Tg vs WT (FDR<0.10, >twofold regulation) compared to expression of the same liver gene set regulated by fasting or CR.
A directed edge in an R-GSN presents a possibility of one gene set regulating another.
SET regulates the G2/M transition by modulating cyclin B-cyclin-dependent kinase 1 (CDK1) activity [ 18].
Bhutia et al. showed that lin28 and SET regulated processing of let-7a in pancreatic cancer cell lines.
In the GZ gene set regulated by the Wnt pathway we found 21 ribosomal genes (whereas none was found in the Hh set).
Work by Kawahara et al. (13) showed that ADAR deamination of the seed region of miR-376 alters the gene set regulated by the edited versus the unedited miRNA.
To obtain a gene set regulated by TGF-β, we used publicly available microarray datasets, derived from two lung fibroblast cell lines stimulated by TGF-β: HFL-1 (GSE27597) and IMR-90 (GSE17518) [ 22, 23].
For example, one yogurt maker provides a factory set regulated temperature with a time - display and cut-off feature.
This will only work in some places, however, where a bargaining culture is acceptable and where set, regulated pricing isn't in place.
GeneChip probe sets regulated by PRDM5 at different time points are summarized in Figure 1B.
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