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"set out to destroy" is a correct and usable phrase in written English.
You can use it to describe the intention of someone to do something malicious, like Iran's attempt to destroy Israel. For example: "The Iranian government set out to destroy Israel with its nuclear weapons program."
Exact(58)
They set out to destroy his administration.
Buyers do not set out to destroy their new prize.
Instead, it set out to destroy his influence.
"I deliberately set out to destroy them, and I did.
There are no deep-pocketed groups who set out to destroy the characters of individual candidates.
From the moment Bill Clinton took office as President, Republicans set out to destroy his legitimacy.
She did not set out to destroy the agreements she helped to create.
"This agency set out to destroy all things Indian," he said at the Sept. 8 celebration.
How Blair's ruthless spin machine set out to destroy this brave woman.
"With the Nouvelle Vague they set out to destroy what came before," he said.
"They did not set out to destroy Citibank, but when you have a large complicated institution, things happen," he said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com