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Discover Ludwig"set off from" is a correct and usable part of a sentence in written English.
You can use it to indicate movement away from a particular place, either physically, or in a figurative sense. For example, "We set off from the house early in the morning, determined to reach our destination by nightfall."
Exact(59)
We set off from King's Cross station.
We set off from our Brooklyn home in a subway car.
We set off from New Orleans at 11 PM—23:00—on Thursday, December 1.
Assamese and Bengali are set off from Oriya.
The following day, David and I set off from Yendouma.
@UADSA_VP_Attila set off from Dundee at 11pm last night.
Few skiers, however, set off from the summit itself.
The head may be set off from the body or grade imperceptibly into it.
The factory was set off from the street in a courtyard.
The town was set off from New Bedford and incorporated in 1812.
The protesters set off from the hospital grounds with a mix of fear and determination.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com