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Pathogen-associated proteins with high F-measure, i.e. proteins that score highly for pathogen or cereal-infecting specificity and conservation, are worthy candidates for putative virulence or pathogenicity factors common to a large set of pathogens.
During this response, keratinocytes produce host defense peptides (HDPs) that have antimicrobial activity against a diverse set of pathogens.
Similarly, one of the tryptophan synthase β subunits, TSB1 is induced by a broad set of pathogens with the exception of X. oryzae.
Each channel has a single output and can be dynamically set to respond to some or all of a set of pathogens.
As seen in Figure 2C and 2D, gene isoforms within tryptophan biosynthesis which are induced by a broad set of pathogens are also diurnally controlled, synchronized and show peak expression at 12 hrs; gene isoforms which are induced specifically or mostly by X. oryzae may or may not be diurnally modulated.
This raises a general question of what genes are broadly expressed when a pathogen stimulates a cell and what genes are only expressed for a specific set of pathogens and cell types.
Similar(41)
Here we designed a putative malaria epitope ensemble vaccine by selecting an optimal set of pathogen epitopes.
At the same time, the procedure gives insight in how the preset optimization criteria leads to the proposed set of pathogen-product combinations.
For pathogen proteins, we used the set of pathogen proteins found to interact with at least one human protein as the universe.
As such, TLR2 seems to be the most promiscuous TLR receptor able to recognize the most diverse set of pathogen-associated patterns [19].
This recognition often occurs via the detection of a set of pathogen associated molecular patterns (PAMPs).
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