The film, called Zaschitniki in Russian, follows a set of mutants who are recruited by the government to fight against an evil supervillain.
A third set of mutants, with deletions or duplications of various lengths and boundaries, lie between the HpaII and BglI sites.
A second set of mutants contains deletions that start at ori and extend unidirectionally for varying lengths towards the HpaII site.
To investigate the role of the gp9 amino terminus, we have engineered a set of mutants with deletions and random substitutions in this part.
We designed a set of mutants affecting putative crucial sites for caleosin function and association with lipid droplets, i.e. the N-terminus, the EF-hand motif and the proline-knot motif.
Using a hyperstable variant of HP36, denoted DM HP36, as our new wild type, we characterized a set of mutants designed to assess the role of the putative gatekeeper interactions.
However, when we focused on a set of mutants that are classified as mutants with GOF activity7,11,34 (i.e. positions R245, R248, R175, R273, R282), we found a significantly positive correlation with poor survival even when grouping the WT + indels patients with other non-GOF mutants (Fig. 5f) (p = 0.03, Kaplan−Meier method; log-rank test).
By using FMTS a set of mutants is generated.
"But this is a very exciting set of mutants".
The set AM is composed by the remaining set of mutants.
Execution of μJava tool in f j and generation of a set of mutants Mf j.
