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The secondary structure is a set of helices containing canonical base pairs (A U, G C, and G U) and contributes to the major part of the free energy of an RNA system.
(B ) The agonist (pink spheres) binding site of P2Y12 receptor is formed by the same set of helices [PDB ID: 4pxz].
Our approach can also be potentially used to detect plausible helix pairings of a certain type in a given set of helices.
BYDV and TNV-D RNAs harbor a BYDV-like CITE (BTE) in the 3′ UTR, defined by a conserved 17-nt sequence that forms part of a set of helices protruding from a central hub [ 13, 17- 19].
The thumb domain is surrounded by the PA-C like domain core lobe and a set of helices (α58 62 and α67) and strands (β31 34), denoted the thumb ring which is structurally homologous to the influenza PB2 N1 and N2 domains.
We considered all possible combinations of 6, 5 and 4 transmembrane helices, within either TM1-TM6 or TM7-TM12, and compared the structure of each set of helices in the L vs T states (closed circles), T vs O (open circles) and O vs L (closed squares), through pairwise root-mean-square difference (RMSD) calculations.
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This algorithm generates a free energy dot plot for a given sequence and recursively searches it for helices or sets of helices that fully match helical walk constraints from NMR.
However, we note here that MMPs dynamically move during functions (Hildebrand et al. 2008) as one MMP complex (complex I) resembles a steam engine in which a piston drives a set of discontinuous helices (Efremov et al. 2010).
This closely mirrors an aforementioned distribution found in a smaller set of α-helices (Chothia et al., 1981), with the shoulder being attributed to segments of 310-helix found at the ends of α-helical regions.
Helanal (Bansal et al., 2000) was used to determine the mean value of n in a set of α-helices extracted from high-resolution structures (<1.6 Å) (Fig. 3a).
The helices form two sets of antiparallel helices, α1-α2 and α3-α4, connected by a very short loop.
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