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Moreover, the process is too inefficient for therapeutic use — 63 oocytes were required to generate one normal set of embryonic cells.
Transformation of somatic cells with a set of embryonic transcription factors produces cells with the pluripotent properties of embryonic stem cells (ESCs).
The set of embryonic morphogenesis genes altered on day 2 differed from those of day 1, now coding for proteins involved in other processes such as axon formation and tissue regeneration (cxcr4b, cdh2, robo2, gap43).
Additional specimens: In the case of species for which only a rare set of embryonic specimens exists as in the case for the echidna Tachyglossus aculeatus [1] or the tuatara Sphenodon punctatus [84] the study of new embryos may fill some gaps in understanding these series.
These studies have reported identification of thousands of maternal genes and identified the earliest set of embryonic transcripts.
The poised promoter set of embryonic stem cells is important in developmental processes and found to be methylated in various cancer types [ 31, 32].
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On the other hand, the role of NCOA4 in erythropoiesis could be limited to the setting of embryonic development and stress erythropoiesis which our zebrafish and K562 model systems are best suited to evaluate.
We collected 8 sets of embryonic chicken (Cobb500 Broiler) skins from both feather and scale regions that represent predicted plastic and differentiated states: E7fe, E7fm, E9fe, E9fm, E9se, E9sm, E11se, and E11sm.
Subsequently, during embryonic neurogenesis, these two homeodomain transcription factors are expressed in specific sets of embryonic NBs in the central brain and are required for the appropriate development of the embryonic brain regions that derive from these NBs (Hartmann et al., 2000; Hirth et al., 1995; Urbach and Technau, 2003; Younossi-Hartenstein et al., 1997).
Here a core set of nine embryonic transcription regulators was found to be overexpressed at the mRNA level in many poorly differentiated tumors, and in the HC11 cells we observed four of these transcription factors to be overexpressed at the stem-like cell stage (Mybl2, Hmga1, Hmgb3, Tead4).
The data set for embryonic development of 8 tissues were described in [18].
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