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Each CGH experiment was attributed a specific set of cut-offs to minimize the number of falsely assigned genes.
To increase the level of agreement between the two DAS28 formulations, one solution would be to derive a new set of cut-off points tailored for use with DAS28 (CRP).
Exploration of a robust method that will translate DAS28 (CRP) to DAS28 (ESR) and the derivation of a corresponding set of cut-off points for the disease activity state for the CRP formulation are needed before a transformation of the DAS28 (CRP) definition is advocated.
The development of a robust approach leading to set of cut-off points that can be generally applied across populations may prove difficult, as illustrated when the translation derived by Inoue et al 23 and Matsui et al 24 is applied to the current dataset.
Since the optimal values for these two cut-offs are not known a priori, we loop over a set of cut-offs on both the values that determine association with a category (e.g. significance of the expression of a gene in a tissue) as well as on 〈 N〉.
We also evaluated PPV and NPV for both sets of cut-offs (data not shown).
The McNemar test for independent samples was used (comparing two sets of data each time) to determine the significance of the differences in the prevalence values of overweight and obesity returned using these different sets of cut-off criteria.
The aim of the study was to determine the prevalence of overweight and obesity in children in Spain using different sets of cut-off criteria, through a community-based cross-sectional study.
Together the two sets of cut-offs give a total of 2413 combinations for the number of genes in a given category and the number of target genes for a given TF.
Procedures utilizing the presence of symptoms or outcomes of prior dipstick testing, to influence the setting of cut-off levels for CFU/mL in urine cultures to label growth as clinically significant, may enhance the diagnostic procedure [ 34].
Procedures utilizing presence of symptoms or outcomes of prior dipstick testing to influence setting of cut-off levels for CFU/mL in urine cultures to label growth as clinically significant may enhance the diagnostic procedure [ 36, 37].
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