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In 1984, Cardinal Law testified, the archdiocese had a "chron file," a chronological set of copies of all outgoing correspondence.
His original set of copies was destroyed by fire in 1718, though de Wit made a second, more-finished set that was later reproduced as engravings.
As the case was being prepared for trial, Steve Howe, the Johnson County prosecutor who took up the case in 2009 after defeating Mr. Kline in a Republican primary, discovered that the records that were to be used as evidence had been destroyed years earlier, the originals by the Department of Health and Environment and the only authenticated set of copies by the attorney general's office.
At each iteration, the program identified repeats with decreasing similarity to the original seed repeat, and the complete set of copies of a particular repeat cluster was obtained.
This suggests that the H2D evolved from an H2′ copy (or set of copies).
However, this method estimates the overall insertion date of the set of copies as a whole, and cannot estimate the insertion date for each individual genomic copy.
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Overlapping CNVs were aggregated to delineate a set of copy number variation regions (CNVRs) [ 27].
If T1 is the set copy number changes of one tumour and T2 the set of copy number changes of another tumour, the events common to both tumours are defined by T1 ∩ T2= c2, c3,…ck,… ck.
A common clonal origin of two tumours can be inferred if they share a set of copy number gains and losses, not likely to be shared at random.
This set of copy number variable genes encompasses a wide spectrum of molecular functions, biological processes, pathways, cellular components and Panther protein classes.
Using this information, we merged segmental values across the genome to create a common set of copy number levels for each individual tumour.
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