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In this paper, we propose to use the theory of locally D-optimal designs to determine the set of concentrations to be tested so that the parameters of the concentration response function can be estimated with high precision.
Differences between group means of the dedicated K d, calculated using the full set of concentrations and the K d, determined using less concentrations of the radioligand with the corresponding 95% confidence intervals (b).
Reliability and effectiveness of the experimental approach were proved by comparing the resulting K d, determined using the full set of concentrations, with the corresponding K d values, calculated from best-fit estimations for the rate constants using two, three, four, five, six or seven concentrations of the radioligand, respectively.
Using multivariate differential calculus, we can determine a critical set of concentrations of the component pMAPKs, which gives rise to the maximal rate of mRNA synthesis.
Continuity of these rate functions then implies the existence of a threshold set of concentrations lower than this critical set, above which the synthesis rate remains over a pre-determined level.
The set of concentrations measurements are given in Table 3 [ 4, 27].
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Physical properties are described by a set of concentration-dependent algebraic equations.
This construct is made tenable by first encoding real-valued sensor concentration observations into a finite set of concentration states.
Uranium VI -ligand aqUranium VI -ligandcounted for aqueoust 99% of dissolved U in eacomplexeson accountedet oforoncentration conditions empleast in this study.
For RoMANS, a new ensemble technique was employed in which input parameters were varied to explore the range, variability, and model sensitivity of source attribution results and statistical measures of model fit over thousands of trials for each set of concentration measurements.
Since Na intercalation in these alloys is accompanied by a substantial volume expansion that can lead to mechanical failure and loss of capacity, we have also obtained a full set of concentration-dependent elastic properties for a single crystal as well as a polycrystalline microstructure.
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