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We identified 11823860_ST2 gene set as the best prognostic gene set for breast cancer patients.
In order to obtain a clinically relevant gene set for breast cancer, our hypothesis was examined under the premise that a particular gene should be present in multiple gene expression profiles despite the differences in methodology used to determine the molecular signature.
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In two large independent gene expression meta-data sets for breast and NSCLC the reduced signature separated the patients into groups with significant distinct survival properties.
At some point, the content of the expression metadata sets for breast cancer will be large enough to sustain continuous activity in data mining, hypothesis generation, and validation.
The results shown in Figure 2 were produced with 150 and 100 samples as training set for the breast cancer and the renal cancer data sets, respectively.
Using this approach, a number of gene signatures were deduced for breast cancer phenotypes, including an "intrinsic" set for clustering of breast cancers [ 6], an "Amsterdam" signature consisting of 70 genes [ 7], a 76-gene "Rotterdam" signature [ 8] for metastasis, and a set of 21 genes associated with disease outcomes for ER+ tumors [ 9].
According to Tiedtke et al. [ 31], meetings with the family, social and professional environment delivering information about the disease and the treatment would back up the adjustments set in place for breast cancer patients and therefore influence the return to work.
"Those are the periods when you get set up for breast cancer.
This tool may be a starting point for local decision makers that would like to conduct multi criteria decision analysis to set priorities for breast cancer control.
The results, published in the previous issue of Breast Cancer Research, are compelling and could inform the way we conduct genetic testing in the diagnosis of LS and set guidelines for breast cancer surveillance in LS mutation carriers.
The methods are applied to GWAS cancer susceptibility SNP sets for lung, breast, prostate and colorectal cancers.
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