Exact(49)
Clr4 belongs to the Su var)3 9 subfamily of histone methyltransferases, an enzyme family with chromo- and SET domains (Rea et al. 2000; Malik and Bhaumik 2010).
Figure 3C shows that the V set domains of TCRs and antibodies share highly structural similarity (in general, RMSD ≤ 2.0 Å).
Our comparison of chromo domains and SET domains from Su var)3-9 and related proteins offers functional predictions concerning both domains in Su var)3-9 proteins.
Therefore, it can be presumed that H3 and H4 histone termini in functioning chromatin are more readily accessible to SET domains (see text above).
We divided host domains into the following sets: domains targeted by any virus (overall set), domains by DNA viruses (DNA set), domains by RNA viruses (RNA set), and domains by retrotranscribing viruses (retro set), as well as domains by different families, genera, and species.
The Chlamydomonas protein contains the PWWP, the FYRN-FYRC (DAST), ePHD, and SET domains in the linear arrangement characteristic for the plant ATX1/2 proteins.
Similar(11)
Both Pre-SET and Post-SET domains have been shown to affect histone methyltransferase activity of the SET domain [ 23, 24].
(DOC 50 kb) Additional file 2: Q-Set Domains.
Both proteins bear hypervariable domains most similar to Ig-like V-set domains.
Locations of SRA, pre-SET, SET, and post-SET domains are shown.
CAMK kinases have fibronectin 3 (fn3) and immunoglobulin I-set domains in a variety of combinations.
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