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The Pre-SET domain close to SET domain is a special character of this subfamily's proteins which assists SET domain in carrying out the enzyme activity.
They can be classified into three groups: SET domain and non-SET domain lysine methyltransferases, and arginine methyltransferases.
The Set1 SET domain mostly resembles the Drosophila 'positive' memory protein trithorax, and the mixed-lineage leukaemia (MLL/HRX/acute lymphocytic leukaemia (ALL -1) SET domALL -1 humanSET
Structure of Ezh1 and its SET domain.
Alvarez-Venegas, R. Bacterial SET domain proteins and their role in eukaryotic chromatin modification.
SET domain containing 6 (SETD6) monomethylates the RelA subunit of nuclear factor kappa B (NF-κB).
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J. et al. Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes.
All insertions were clustered very tightly at the start of the SET domain-containing gene, Prdm14.
PKMTs are further subdivided into su var)3-9, enhancer of zeste, trithorax (SET) domain-containing, and non-SET domain-containing proteins.
Structure of the catalytic domain of human Dot1L, a non-SET domain nucleosomal histone methyltransferase.
Its highest scoring partner is the Pre-SET domain in all these organisms except in yeast (which lacks the Pre-SET domain).
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