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Though not included in the initial gene set correlation analysis, our PGC-1α over-expression signature was also negatively correlated with FLCN expression (rho, -0.60, p < 0.0001).
The resulting optimal multivariate nonlinear QSPR models involve the five basic sigma-moments having defined physical meaning and possess superior predictive ability for dispersion, polar and hydrogen bonding HSPs components, with test set correlation coefficients R2d = 0.85, R2p = 0.91, R2h = 0.92 and mean absolute errors of Δδd = 1.37 MPa1/2, Δδp = 1.85 MPand2 and Δδh = 2.58 MPa1/2.58
Each probe set correlation with BDNF that passed the threshold was defined as a "link".
Each probe set correlation with BDNF that passed the threshold was termed as a "link".
The increasing or decreasing of GS score represents the degree of gene set correlation with phenotype.
Inter-chip set correlation can be utilized as a criterion to distinguish low signals from the noise.
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For each probe set, correlations were calculated on average over 27340 other probe sets.
Because this filtering may affect correlations and include comparisons of 1 kb filtered and unfiltered data set, correlations are presented in supplementary table S1 (Supplementary Material online).
Therefore an appropriate correction procedure should reconstitute the perturbed real inter-chip set correlations of expression profiles and eliminate the irrelevant ones.
The results give strong evidence of the reproducibility of internal correlations (low standard errors in Figure 2), with strong agreement of gene set correlations between platforms (Spearman cor.: 0.719 - 0.862).
In this case, we ranked the 22,283 probe sets measured by the U133A gene chip based on the probe sets' correlation with pCR.
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