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The clinical trial population does not map onto the whole population of women with HER2-positive breast cancer, some of whom, on the basis of arbitrarily set cardiac criteria, are excluded from receiving trastuzumab, even though they might benefit from treatment without long-term adverse cardiac sequelae.
Frequency analysis of the 834 citations identified five high frequency natural language alternatives that could improve retrieval of this set (cardiac failure, cardiac resynchronization, left ventricular systolic dysfunction, left ventricular diastolic dysfunction, and LV dysfunction).
Since in-hospital complications, such as cardiogenic shock, occurred infrequently, a variable summarizing the data on all complications available in the data set (cardiac arrest, pulmonary edema, bradycardia, re-infarction, ventricular tachycardia, ventricular fibrillation, cardiogenic shock) was created (yes/no).
Intradermal administration deposits a depot of contrast agent that is gradually taken up by the lymphatic capillaries to form multiple boluses over time, eliminating both the need to inject multiple boluses of contrast agent directly into an artery and the need to time the injections with a set cardiac rhythm.
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Setting: Cardiac intensive care unit, university hospital.
Setting: Cardiac surgery unit at a university teaching hospital.
Setting: Cardiac surgical unit in a university teaching hospital.
In this setting cardiac imaging methods can provide the clue to obtaining the diagnosis.
In the clinical setting, cardiac magnetic resonance imaging (MRI) and blood pool single-photon emission computed tomography are considered as gold standards for the assessment of LVEF [5 7], but have not found wide use for monitoring cardiac therapies in mice.
Fifteen experts and two coordinators agreed to consider questions concerning TTM and its practical implementation in five clinical situations in the intensive care setting: cardiac arrest (CA), traumatic brain injury (TBI), stroke, other brain injuries, and shock.
In this setting, cardiac injury may be associated with or precipitate a fatal outcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com