However it is noteworthy that CPF males are affected throughout all the sessions of the social recognition test, an effect more evident during the first two session of the test.
CPF male mice showed higher social investigation (total sniffing) in each session of the test than STD mice [F (1, 17) = 8.42 p = 0.001].
First, we investigated the effects of a bolus oral gavage of T2 (see drug administration below) to C57BL6J mice at the dose of 250 mcg/kg either 30 min before (n = 7) or 2 h after (n = 8) the first tail suspension session of the test and 1(c)), as described previously [ 26, 32, 36]; control groups constituted 8 mice in each experiment.
Selection of the appropriate requirement that coincides with your degree is needed in the afternoon session of the test.
Data from the first testing session of the 30MW test were used in the regression analyses.
USV emission, normally emitted during a female-female social encounter in a resident-intruder paradigm [ 41], follows exactly the same profile of social investigation throughout the three sessions of the test.
As for the emergence test, Rac1N showed a highly significant increase in the total distance traveled in both sessions of the test (genotype effect, F1,24 = 25.94, P = 0.0002, Fig. 1 F and Supplementary Fig. 1 E ) and in the speed (genotype effect, F1,24 = 15.7, P = 0.0006, data not shown).
Post hoc comparisons revealed that both lesioned groups (Don-Sap and Sal-Sap) tended to exhibit motionless time lower than that of sham animals (Don-Sham and Sal-Sham) in the final sessions of the test (S6: P = 0.02; S7: P = 0.07).
Significant changes were also observed for the number of errors, which decreased from 0.8 ± 0.9 in the pre session of the standard test to 0.1 ± 0.3 in post (p = 0.015) and 0.6 ± 0.8 in rec-96 h session (p = 0.352).
As many of the children were not acquainted with computers, a 'mouse-training' session was part of the testing procedure.
