At the molecular level, artemisinins are initially activated by the cleavage of the endoperoxide with intracellular heme iron [5, 13].
It appears that iron-mediated cleavage of the endoperoxide bridge plays a vital role in achieving their anti-cancer properties.
The long fluorescence lifetime of the endoperoxide (2.76 ms) allows the probe to be used favorably for time-resolved fluorescence detection of 1O2.
ARS exert its anti-malarial activity by generation of organic free radicals through cleavage of the endoperoxide bridge.
ARS has been shown to exert its anti-malarial activity by generation of organic free radicals through cleavage of the endoperoxide bridges [7].
Fe++-dependent activation of the endoperoxide bridge is required for the drug to be active [ 49].
Cleavage of the endoperoxide moiety forms highly reactive oxyl radicals that rearrange to more stable carbon-centered radical intermediates.
The decrease in absorbance, due to the loss of conjugation, has been used for anthracene derivatives as a quantitative measure of the formation of the endoperoxide.
A session of the legislature.
Open a session of the Safari browser.
