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The amphipathic agents surround the hydrophobic segments of MPs, thus serving as a membrane mimetic system.
This finding suggests that the TM domains have additional functions and are not just serving as a membrane anchor.
Among these Rab effectors, we demonstrated that MICAL-L1 is a key player in the control of the slow recycling pathway by serving as a membrane hub to recruit regulators to the recycling endosomes.
Complement protein component c7 (87896_2052 on LG6, Table 5) plays an important role in the membrane attack system of the innate and adaptive immune response by serving as a membrane anchor, facilitating the formation of pores in the plasma membrane of target cells [ 46].
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A hypothesis is presented according to which the α9 helix of C-terminal region in PLA1 not only controls the opening of lid but also serves as a membrane anchor that assists in binding to PC.
Htt17 is of fundamental importance: it serves as a membrane anchor to control the localization of huntingtin, it modulates huntingtin's function through posttranslational modifications, and it controls the self-assembly of the amyloidogenic QN segment into oligomers and fibrils.
A few type II proteins have a uncleaved, N-terminal signal sequence, but unlike the case of Ctm-PrP, this sequence serves as a membrane anchor[23].
The lyn-mRFP is an mRFP that contains the lyn kinase at its N-terminus, which serves as a membrane localization signal but does not affect neither transcription and translation [34].
In contrast, other mutants with single genes defected at wzzE, which relaxes the regulation of the length of membrane O-antigen [21], csgB, which functions in curli nucleation [22], or ompE, which serves as a membrane porin, retained preferentially the pattern of daughter cells sliding in parallels (>80%) (Table 3).
It is notable that the basic charge at position 683 is >99.9% conserved in subtype C (either as K or R), and has been proposed to serve as a membrane anchor/MSD stop signal [53] yet we observed frequent substitutions at this position linked to the presence of a G or R at position 680.
GPI serves as a membrane anchor for a variety of cell wall associated proteins.
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