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Yet, only very little was known about the molecular switch, which serves as the checkpoint for the distinct consequences, that is, activation versus hyporesponsiveness or death of T cells.
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CENP-F is a nuclear protein associated with the centromere-kinetochore complex, which monitors chromosome-microtubule interactions and serves as the source of checkpoint signals.
To avoid checkpoints, drivers walk their motorbikes across the thin, shallow waters of the Táchira river that serves as the border between the two countries.
This serves as the pupils.
This serves as the topping.
We show that IF1 expression serves as a checkpoint for the release of Cytochrome c (Cyt c) and hence the completion of the apoptotic program.
LRPPRC therefore serves as a checkpoint protein for the initiation of basal levels of autophagy and enhances the removal of dysfunctional mitochondria and other cellular debris.
It will also be important to understand whether Zfp335 acts constitutively during late stages of T cell development or whether its function is regulated by external inputs and thus serves as a checkpoint that can influence the size and properties of the naïve T cell compartment.
Synthesis of the viral encoded transactivator, BZLF1 also referred to as Zta or ZEBRA) serves as a checkpoint for initiation of the replicative cycle [15].
This time, however, many of the missions are broken into segments, and each segment serves as a checkpoint for any subsequent replays.
Recent study showed that the ATM-BID pathway serves as a critical checkpoint in the homeostasis and DNA-damage-induced cell death of HSCs (Maryanovich et al., 2012).
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