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Our data also reveal that LoNA serves as a sensor of neuronal activities and its levels are reduced rapidly upon neuronal stimulation, therefore leveraging rRNA production and subsequent protein synthesis, including synaptic proteins.
Keap1 is a cysteine-rich protein that serves as a sensor of oxidative and electrophilic stress.
The ARF (alternative reading frame; p14ARF in human, p19Arf in mouse) tumor suppressor serves as a sensor of hyper-proliferative signals, resulting in p53-dependent growth arrest and apoptosis [1], [2], [3].
The mammalian target of rapamycin (mTOR) serves as a sensor of mitochondrial homeostasis in T cells and is activated in SLE patients.
Moreover, it also stabilizes kinetochore microtubule attachments and serves as a sensor of SAC by binding to and regulating the activity of BubR1.
Zinc is an oxidation-neutral metal that often protects cysteines from oxidation or serves as a sensor of the cysteine oxidation state [ 36].
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ATFS-1 by contrast serves as a sensor for general levels of mitochondrial stress.
AdPG served as a sensor of p53 activity in LNCaP cells treated with chemotherapeutic agents.
Thus, in mosquitoes, heme is an important signaling molecule, serving as a sensor of the availability of a protein meal for egg development.
The Hippo pathway may thus serve as a sensor of tissue structure and mechanical tension, integrating information regarding the size and shape of an organ into cellular behavior, such as whether or not to proliferate.
Thus, IRF4 served as a sensor of BCR signaling strength, translating it into a binary cell fate decision 32.
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