The serum pepsinogen level is widely accepted as a useful parameter for monitoring gastrointestinal nematode infections in first-season grazing calves.
Faecal egg counts (FEC), body weights, FAffa MAlan CHArt (FAMACHA®) scores, packed cell volumes (PCV), red blood cell counts, total and differential white blood cell counts, blood haemoglobin contents, serum total protein and albumin contents, and serum pepsinogen and antibody levels were determined at 0, 28, 28, 35 and 42 days after challenge.
In a human study of 12-wk ingestion (BF-1 group, n = 40; placebo group, n = 39) with a randomized double-blind placebo-control design, the H. pylori urease activity and gastric situation were evaluated using a urea breath test (UBT) and the serum pepsinogen (PG) levels as biomarkers for inflammation or atrophy, respectively.
In addition, many studies have shown that serum pepsinogen I (PG I) [28, 29], pepsinogen II (PG II) [30], PG I/PG II ratio [31, 32], and Helicobacter pylori (H. P). [33 35] are also associated with an increased risk of gastric cancer.
Serum pepsinogen I and II (PGI and PGII) concentrations of serum collected at the first endoscopy from individuals in the Kalixanda study were measured by enzyme immunoassay (EIA; Biohit Plc, Helsinki, Finland) according to the manufacturer's instructions.
During this period, six individuals progressed from low grade atrophy to severe atrophy or gastric adenocarcinoma, two individuals with initially normal mucosa established atrophy and nine individuals had normal mucosa at both occasions, as indicated by both histology and serum pepsinogen levels.
As expected, serum pepsinogen was lower in the indoor animals.
Serum pepsinogen was measured as a marker of the mucosal integrity.
Serum pepsinogen (PG) I and II levels were measured using enzyme-linked immunosorbent assay kits.
Serum pepsinogen (PG) levels are valuable in the diagnosis of gastric diseases.
The serological assessment of gastric atrophy by analysis of serum pepsinogen is only adequate for patients with intestinal type cancer.
