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As we analysed representative tissue specimens from the central areas of only serous stage III ovarian carcinomas, selected by an experienced pathologist to reflect about 60% tumour and 40% stroma content, the distribution of tumour/stroma was taken into account.
The aim of this study was to investigate the prognostic effect of tumour-infiltrating lymphocytes (TILs) in serous stage III ovarian carcinoma to determine TIL clonality and to correlate this to Her2/neu expression.
In this study, we further clarified and validated the prognostic significance of TILs in ovarian carcinoma, by focussing on the exact location of TILs within the tumour mass, in a homogeneous group of serous stage III ovarian carcinoma patients and the clinically important sub-groups of optimally debulked and paclitaxel/carboplatin-treated patients.
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These included two patients with papillary serous carcinoma (stage III and IV) and one patient with stage 2 endometrioid carcinoma.
Altogether, 264 cases with serous EOC stage II to IV, suboptimal debulking, and platinum-containing treatment were selected.
The performance of the simple rules was poor for abscesses, fibromas, and serous borderline stage I tumours.
One patients with papillary serous adenocarcinoma stage IIIc that received 4 course of taxol plus carboplatin (T+C) from 20 weeks of gestation.
Histological examination of the tumor tissue samples obtained at surgery classified all six patients as having a serous subtype (stage IV).
The ovarian dataset [ 70] was stratified by malignant or low malignant potential, histological type (endometrioid or serous), grade, stage and primary site (ovary, peritoneum or fallopian tube).
We categorized these samples according to four different clinicopathologic parameters: age (<50 years or ≥50 years), histological types (Mucinous or <span class="lh">Serous), FIGO stage (I, II or III), Differentiation grade (G1, G2, G3) (Table 1).
The aim of this study was to characterise the presence and exact localisation of TILs by immunohistochemistry in a homogeneous group of 100 serous FIGO stage III ovarian carcinoma patients treated by different adjuvant chemotherapy protocols.
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