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The reason behind this discrepancy could be differences in serotype composition reported by the studies.
Phylogenetic groups (PGs) determined by Bayesian analysis of population structure clustering are boxed within dotted lines, with the geographic and serotype composition of isolates in each PG being inlaid as pie charts.
Mathematical models can be used to elucidate these contrasting outcomes, predict the conditions under which serotype replacement is likely, interpret the results of conjugate vaccine trials, design trials that will better detect serotype replacement (if it occurs), and suggest factors to consider in choosing the serotype composition of vaccines.
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There are 35 serotypes described and the composition of the capsule defines the serotype (types 1 34 and 1/2).
Here, we present a descriptive epidemiology of the serotype and sequence type composition of invasive pneumococcal isolates during the early stages of the PCV7 implementation in Singapore.
We were interested in evaluating the effects of vaccine introduction on the prevalence and clonal composition of serotype 19A among isolates from IPD in German children <16 years of age.
The aim of the current study was to determine possible changes in the rate of reported infections and the clonal composition of serotype 19A IPD isolates before and after the widespread use of PCV7 in 2006 in Germany, and to evaluate possible factors driving these epidemiological changes, including PCV7 uptake and antibiotic usage.
Enteroviruses were present in all four periods, but the composition of serotypes dramatically shifted from coxsackieviruses in 2006 to primarily echoviruses in 2007.
However, sequencing remains a laborious and expensive technique, making it difficult to obtain answers concerning the genetic composition of serotypes, or newly emerged variants of interest in a timely manner.
We also applied Fisher's exact test to assess difference in ST composition within each serotype and found no significant difference between the 2009 and the 2011 samples.
When the clonal composition of the serotype 19A isolates before and after the start of the pneumococcal conjugate vaccine recommendation in July 2006 was compared, several changes in clonal composition could be observed.
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