Sentence examples for serotonin receptor affinity from inspiring English sources

We hypothesized that antipsychotics, which share antagonism at dopamine receptors, with a relatively low dopamine receptor affinity and high serotonin receptor affinity may have a sparing effect on prefrontal function compared to strong dopamine receptor antagonists.

While multiple methodologic limitations must be considered, these results suggest that antidepressants with lower serotonin receptor affinity may be preferred in patients at greater risk for such complications.

Serotonin 5-HT2C receptor affinity is also negatively correlated with the dose of typical neuroleptics.

24 This may be because, as they noted, venlafaxine has a lower affinity for the serotonin receptor than do most selective serotonin reuptake inhibitors, 25 but to compensate for its lower potency in vitro, a threefold to sevenfold greater daily dose is usually prescribed.

The compounds were tested for their affinity for human 5-HT7 sereceptorreceptor.

Psilocin has a high affinity for the 5-HT2A sereceptorreceptor in the brain, where it mimics the effects of serotonin (5-hydroxytryptamine, or 5-HT).

Various subtypes of serotonin receptors with different affinities and intracellular effects are differentially distributed in the ventral and dorsal parts of the striatum [29], [30].

Similarly, antidepressants other than SSRIs might decrease platelet activation and aggregation by antagonizing the serotonin receptor and/or inhibiting also serotonin reuptake, although with lower affinity than SSRIs [ 3, 4].

HRMS calculated for C19H20F3N2O [M + H]+, 349.15222; observed [M + H]+, 349.15259 Receptor affinity values for a panel of human serotonin receptors were obtained for all compounds through the NIMH-sponsored PDSP program (www.pdsp.med.unc.edu).unc.edu

The concept of bioisosteric replacement matrices is applied to explore the chemical space of serotonin receptor ligands, aiming to determine the most efficient ways of manipulating the affinity for all 5-HT receptor subtypes.

This compound exhibited a binding affinity value of 0.094 nM toward human 5-HT4R and a high selectivity over other serotonin receptor subtypes (5-HTR).