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Investigators are already facing serious technical obstacles.
The 43 winners were announced on June 28th.The Grand Challenges are 14 serious technical obstacles to a healthier world (see table) that were picked by the committee in the autumn of 2003, after its members had gone through several thousand submissions from the world's medical scientists.
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On the one hand, telecoms companies have spent vast sums on licences for third-generation (3G) wireless services but are facing serious financial and technical obstacles to building networks.
Yes, there are legal and technical obstacles; but, at the local level, a few states, including Georgia, California and, thank God, Florida, are engaged in serious overhauls of their voting systems (Ms Harris is introducing machines that may not be perfect but are still improvements).
Nor are the technical obstacles trivial.
But Ms. Conrad said many legal and technical obstacles remained.
"There are a lot of technical obstacles to overcome.
Technical obstacles, financial obstacles, having to find people who provide the content.
It would be implausible enough even before the technical obstacles.
There's no principled reason to think that any of these technical obstacles are insurmountable, though.
There are also technical obstacles - helicopters are harder to fly than fixed-wing planes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com