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The absence of such important data can potentially present serious specification problems for traditional statistical analyses that can lead to biased and inconsistent parameter estimates, erroneous inferences and erroneous accident predictions.
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Moreover, size constraints on the evolution of STRs, absent in SNPs, can lead to serious mis-specification of branch lengths and topology of phylogenetic trees [ 43].
In addition to discordant counts, problems were lack of provision of crude death numbers even when death was an outcome of interest (Cases 1 and 3), imprecision in data entry (Case 4), reporting of deaths under serious adverse events without specification as to whether they were counted as part of the death outcome (Case 4) or the participant flow (Case 7).
This has serious implications for the model specification.
Choose good backpack specifications.
If the concentration of any parameter is above the prescribed limit (according to WHO and BIS specifications) there can be serious health issues.
The equipment and instruments were tested and calibrated with calibration blanks and serious of calibration standards as per specifications outlined in standard methods of water (APHA et al. 1998).
It should be noticed that molecular phylogeny methods that employ sophisticated models of sequence evolution, usually within the maximum likelihood framework, are not without their own serious problems that are related, mostly, to model over-specification and mis-specification (proverbial attempts to "fit an elephant") [ 42- 45].
For example the DCS diagnostics for the front-end (FE) chips is a serious option being considered that needs an early requirement and specification definition.
However, the report implicating serotonin in GRP specification suggested that inhibition of serotonin signaling causes serious patterning defects in treated embryos, including altered specification of the superficial mesoderm (Beyer et al., 2012), a phenotype we never observed with our reagents but one that could potentially contribute to non-specific laterality defects due to toxicity.
The fact that most studies completely lacked a description and specification of follow-up method or time should raise more serious concerns.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com