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Serious pathogens of many cultivated plants causing extensive damage and losses to agriculture and forestry include the rice blast fungus Magnaporthe oryzae, tree pathogens such as Ophiostoma ulmi and Ophiostoma novo-ulmi causing Dutch elm disease, and Cryphonectria parasitica responsible for chestnut blight, and plant pathogens in the genera Fusarium, Ustilago, Alternaria, and Cochliobolus.
Morbilliviruses have emerged as serious pathogens of cetaceans and pinnipeds worldwide (1 ).
Staphylococcus aureus is one of the most serious pathogens of humans and important animal pathogen.
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Aphanomyces euteiches Drechsler is a serious pathogen of leguminous crops that causes devastating root rot of pea worldwide.
P. infestans is the most serious pathogen of potatoes on a worldwide basis and control of this windborne pathogen is achieved only by a significant expenditure of pesticides [2].
Vibrio is a serious pathogen of marine fish and invertebrates, particularly penaeid shrimp [ 27].
The best-known phlebovirus is Rift Valley fever virus, a serious pathogen of ruminants but also capable of causing disease, sometimes fatal, in man [ 7,8].
Similarly, the introduced ascomycete O. novo-ulmi has become a serious pathogen of a major tree species and represents a good candidate for virus-mediated control.
Only limited data were available for other members of the Francisella genus, including F. philomiragia, an opportunistic pathogen of humans, F. noatunensis, a serious pathogen of farmed fish, and other less well described endosymbiotic species.
Recently, IMPDH has emerged as an attractive target for drugs against Cryptosporidium parvum, the intracellular eukaryotic parasite that is a major cause of diarrhea and malnutrition in the developing world and a serious pathogen of AIDS and other immunosuppressed patients in the industrialized world (4– 6).
Spirochete (order Spirochaetales), also spelled spirochaete, any of a group of spiral-shaped bacteria, some of which are serious pathogens for humans, causing diseases such as syphilis, yaws, Lyme disease, and relapsing fever.
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