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'serious negative impact' is correct and usable in written English.
You can use it when talking about the effect of something on something else, whether it's the effect of a policy on a population, or the effect of an action on a situation. For example, "The decision to close the factory had a serious negative impact on the local economy."
Exact(38)
This has a serious negative impact.
The upheaval had a serious, negative impact on the economy.
Cuts in disability benefits, local government services and science funding will all have a serious negative impact on cancer patients.
Of course, while there's scant evidence that immigration damages the environment, it's pretty clear that current efforts to curb illegal immigration are having a serious negative impact.
"Any queues that develop as a result will be highly visible and could have a serious negative impact on business, trade and tourism.
I'm confident at the end of the day that they understand that significant losses or loss of control will have a terribly serious negative impact on his presidency".
Similar(22)
It simply points out that climate change can have serious, negative impacts.
Let us agree that human activity is changing our climate and that global warming will have serious, negative impacts.
The intensification of agriculture entails the simplification and homogenisation of the landscape, which has serious negative impacts on animal biodiversity.
Also discuss how far the conventional building practicing and construction activities lead to many serious negative impacts on our natural environment.
Wind energy is seen by the public opinion as a source of local employment and development path of the environment, without serious negative impacts on the environment.
More suggestions(16)
serious negative effect
drastic negative impact
extreme negative impact
major negative impact
strong negative impact
substantial negative impact
tremendous negative impact
severe negative impact
enormous negative impact
serious negative affect
devastating negative impact
serious negative implications
serious negative repercussions
serious adverse impacts
serious negative effects
serious adverse impact
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com