There will be some serious methodological challenges to doing that, of course.
At the same time, there are serious methodological challenges, questioning, for example, the use of individuals' self-reports of how happy they are and the effort to objectify and even quantify so subjective and elusive a quality as happiness.
However, the review also reveals that there are serious methodological challenges and shortcomings in existing empirical approaches, namely with regard to definitional issues, the development and use of instruments, selection of samples, study designs and the inclusion of mediating or moderating variables.
However, the use of QALYs in child health care poses serious methodological challenges which must be considered carefully in the search for an appropriate outcome measure [ 30, 31].
Although many traditional systems in Latin America have proved their durability in the long term, researchers face serious methodological challenges inherent in measuring the relationship between biodiversity and food security within a common framework.
It also influenced the policy discourse [11], [12] and resultant demands on accounting tools [2], [14] leading to some serious methodological developments and challenges.
Limited standardisation in defining injuries has repeatedly been reported as a serious methodological pitfall when comparing study outcomes [ 13, 31] and has been identified as a substantial methodological challenge for future studies [ 32].
There is also a serious methodological issue.
Research on this topic has serious methodological and theoretical limitations and biases.
It is true that this approach, too, comes with serious methodological caveats, such as verifiability, selection bias or observer bias.
