Sentence examples for serious limitations including from inspiring English sources
Presently, bone grafting is the gold standard for bone repair, but presents serious limitations including donor site morbidity, rejection, and limited tissue regeneration.
Although well-established laser confocal microscopy can be used for these purposes, this technique has serious limitations including penetration depth and availability.
Like the ones conducted in adults, these studies have serious limitations, including administration of the drug in desperate cases and evaluation of small numbers of patients.
However, the use of x-rays to assess and quantify structural changes over time does present some serious limitations, including the fact that this technology does not permit direct visualization of cartilage) [ 4- 7].
Family Doctors in one Canadian study reported rarely using FOB testing for screening due to a number of serious limitations, including low yield, high rates of false positives and false negatives, and a number of technical problems [ 12].
However, some serious limitations including inherent toxicity, poor biocompatibility, and lack of multiplexed imaging and analytical systems should be systematically improved to further promote their use in cancer studies.
Cancer treatment through chemotherapy has serious limitation including resistance for cancer cells to these chemicals [ 31].
However, current erythropoiesis-stimulating agents (ESAs) have limitations, including undesirable and serious side effects (cardiovascular and tumour-promoting), high cost of manufacture and non-convenient routes of administration (Lombardero et al, 2011).
Conventional cancer treatment modalities have several limitations including lack of sufficient efficacy, serious untoward toxicity, as well as innate and acquired drug resistance.
Although this approach has been seen as a major step in the expansion of personalized medicine, it has substantial limitations including its high cost and the presence of serious adverse effects.
12 However, iv phenytoin has several limitations, including drug level monitoring, liver enzyme elevation, rare but serious skin reactions, and significant drug interactions.
